全文获取类型
收费全文 | 9275篇 |
免费 | 1003篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 60篇 |
儿科学 | 288篇 |
妇产科学 | 193篇 |
基础医学 | 1226篇 |
口腔科学 | 207篇 |
临床医学 | 1049篇 |
内科学 | 1749篇 |
皮肤病学 | 88篇 |
神经病学 | 723篇 |
特种医学 | 293篇 |
外国民族医学 | 1篇 |
外科学 | 1935篇 |
综合类 | 316篇 |
一般理论 | 12篇 |
预防医学 | 912篇 |
眼科学 | 166篇 |
药学 | 554篇 |
中国医学 | 7篇 |
肿瘤学 | 517篇 |
出版年
2023年 | 76篇 |
2021年 | 205篇 |
2020年 | 142篇 |
2019年 | 209篇 |
2018年 | 251篇 |
2017年 | 193篇 |
2016年 | 164篇 |
2015年 | 200篇 |
2014年 | 293篇 |
2013年 | 411篇 |
2012年 | 540篇 |
2011年 | 557篇 |
2010年 | 332篇 |
2009年 | 275篇 |
2008年 | 435篇 |
2007年 | 495篇 |
2006年 | 451篇 |
2005年 | 403篇 |
2004年 | 395篇 |
2003年 | 372篇 |
2002年 | 355篇 |
2001年 | 224篇 |
2000年 | 209篇 |
1999年 | 192篇 |
1998年 | 106篇 |
1997年 | 92篇 |
1996年 | 68篇 |
1995年 | 81篇 |
1994年 | 78篇 |
1993年 | 54篇 |
1992年 | 179篇 |
1991年 | 171篇 |
1990年 | 157篇 |
1989年 | 127篇 |
1988年 | 127篇 |
1987年 | 105篇 |
1986年 | 129篇 |
1985年 | 116篇 |
1984年 | 91篇 |
1983年 | 82篇 |
1982年 | 58篇 |
1981年 | 50篇 |
1979年 | 85篇 |
1978年 | 77篇 |
1976年 | 52篇 |
1975年 | 53篇 |
1974年 | 57篇 |
1973年 | 71篇 |
1972年 | 70篇 |
1971年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 30 毫秒
991.
Vansant G Trauger RJ Cameron A Vendemelio M Kreitschitz S Carlo AT Banaszczyk MG Carlo DJ Hendler S Ill CR 《Autoimmunity》2007,40(3):180-186
Propofol hemisuccinate is a prodrug water soluble form of the lipophilic, phenolic compound propofol (2,6-di-isopropylphenol), that is the active ingredient in the widely used anesthetic agent Diprovan. Propofol binds to GABA(A) receptors but also has a phenolic structure that confers antioxidant properties to the molecule. The effects of propofol hemisuccinate in rat experimental autoimmune encephalomyelitis (EAE) were studied using different doses and time regimes. Propofol hemisuccinate, 100 mg/kg given three times a day from day 7 or day 12 until day 16 after disease initiation, significantly reduced maximal EAE score. Histology studies supported the clinical findings demonstrating reduction in the inflammatory response in the lumbar spinal cord in animals treated with propofol hemisuccinate. Decreased levels of nitrotyrosine and unchanged levels of induced nitric oxide synthase suggest propofol hemisuccinate crossed the blood brain barrier and exerted its effects by lowering reactive oxygen species levels. The results suggest that propofol hemisuccinate may provide an alternative mode of treatment for acute exacerbations of multiple sclerosis. 相似文献
992.
Everett B Cameron B Li H Vollmer-Conna U Davenport T Hickie I Wakefield D Vernon S Reeves WC Lloyd AR 《Genes and immunity》2007,8(8):699-702
Coxiella burnetii is a macrophage-tropic, Gram-negative organism, which causes acute Q fever infection in humans. This zoonotic infection causes illness ranging from asymptomatic seroconversion to severe and protracted disease featuring hepatitis and pneumonia. Interactions between C. burnetii lipopolysaccharide (LPS) and host Toll-like receptors (TLR)-2 and -4 have been implicated in pathogen recognition, phagocytosis and signaling responses. Nonconservative single nucleotide polymorphisms in the coding regions of TLR-2 (Arg677Trp and Arg753Gln) and TLR-4 (Asp299Gly) have been found to correlate with mycobacterial infections and Gram-negative sepsis respectively. Associations between the TLR-2 and -4 polymorphisms, illness characteristics and immune response parameters were examined in subjects with acute Q fever (n=85) and comparison subjects with viral infections (n=162). No correlation was demonstrated between these polymorphisms and susceptibility to Q fever, illness severity or illness course. 相似文献
993.
994.
Some disease-associated ancestral haplotypes carry a polymorphism of TNF 总被引:12,自引:0,他引:12
R L Dawkins A Leaver P U Cameron E Martin P H Kay F T Christiansen 《Human immunology》1989,26(2):91-97
We describe here an Nco I restriction fragment length polymorphism of tumor necrosis factor carried by the 8.1 (HLA-A1,B8,BfS,C4AQ0,C4B1,DR3) and the 44.1 (HLA-B44,BfS,C4A3,C4BQ0,DR4) ancestral haplotypes associated with complications of rheumatoid arthritis. By examining multiple examples of these and other ancestral haplotypes it was seen that 8.1 and 44.1 ancestral haplotypes yield fragments of approximately 5.5 kb while many other ancestral haplotypes carry fragments of approximately 10.5 kb. The polymorphism is associated with the ancestral haplotype rather than the HLA-B or -DR allele defined by conventional serology. 相似文献
995.
Cardinal JW Bergman L Hayward N Sweet A Warner J Marks L Learoyd D Dwight T Robinson B Epstein M Smith M Teh BT Cameron DP Prins JB 《Journal of medical genetics》2005,42(1):69-74
Introduction: Mutation testing for the MEN1 gene is a useful method to diagnose and predict individuals who either have or will develop multiple endocrine neoplasia type 1 (MEN 1). Clinical selection criteria to identify patients who should be tested are needed, as mutation analysis is costly and time consuming. This study is a report of an Australian national mutation testing service for the MEN1 gene from referred patients with classical MEN 1 and various MEN 1-like conditions. Results: All 55 MEN1 mutation positive patients had a family history of hyperparathyroidism, had hyperparathyroidism with one other MEN1 related tumour, or had hyperparathyroidism with multiglandular hyperplasia at a young age. We found 42 separate mutations and six recurring mutations from unrelated families, and evidence for a founder effect in five families with the same mutation. Discussion: Our results indicate that mutations in genes other than MEN1 may cause familial isolated hyperparathyroidism and familial isolated pituitary tumours. Conclusions: We therefore suggest that routine germline MEN1 mutation testing of all cases of "classical" MEN1, familial hyperparathyroidism, and sporadic hyperparathyroidism with one other MEN1 related condition is justified by national testing services. We do not recommend routine sequencing of the promoter region between nucleotides 1234 and 1758 (Genbank accession no. ) as we could not detect any sequence variations within this region in any familial or sporadic cases of MEN1 related conditions lacking a MEN1 mutation. We also suggest that testing be considered for patients <30 years old with sporadic hyperparathyroidism and multigland hyperplasia. U93237相似文献
996.
997.
Chimowitz MI Lynn MJ Derdeyn CP Turan TN Fiorella D Lane BF Janis LS Lutsep HL Barnwell SL Waters MF Hoh BL Hourihane JM Levy EI Alexandrov AV Harrigan MR Chiu D Klucznik RP Clark JM McDougall CG Johnson MD Pride GL Torbey MT Zaidat OO Rumboldt Z Cloft HJ;SAMMPRIS Trial Investigators 《The New England journal of medicine》2011,365(11):993-1003
998.
Biggs SN Pizzorno VA van den Heuvel CJ Kennedy JD Martin AJ Lushington K 《Behavioral sleep medicine》2010,8(4):207-218
Caucasian (N = 47) and Southeast (SE) Asian (N = 36) families completed a questionnaire on their attitudes toward sleep, as well as a 7-day sleep diary for their children aged 5 to 11 years. Cultural differences were found in the perceived importance of sleep, particularly compared to homework and belief of how much sleep a child needs. Differences were also found in sleep-wake behaviors and amount of time spent on homework, with SE Asian children reporting a shift in sleep timing and increased homework load compared to Caucasian counterparts. Parental attitudes toward sleep, perception of sleep need, and homework load were not associated with the regulation of actual sleep behaviors in children, regardless of cultural heritage. 相似文献
999.
1000.